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Nevertheless, a scientific foundation has been lain for the further assessment of potential targeted molecules and the rational design of polytherapies to maximize clinical efficacy
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Clinically, \an GCN2 inhibitor, APL-4098, has been studied in a phase 1 trial for acute myeloid leukemia (AML), where it was well tolerated and reduced AML blast counts in 5 out of 9 of the patients (141)
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