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Chemical proteomics studies in HT1080 cells revealed that during ferroptosis, several carbonylated residues resulted from oxidized lipids insertion (rather by direct oxidation from ROS), and that oxidized voltage-dependent anion-selective channel protein 2 (VDAC2) may be responsible for mediating ferroptosis
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The opposite will be true for sensors whose DNA-affinity is tightened upon metal binding, for example co-repressors such as Zn(II)-sensing Zur
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