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Serine protease is closely associated with mood and cognitive function, and a decline in its levels in the body may cause anxious behavior.45 Consequently, this could be a potential mechanism underlying the anxiety experienced by tinnitus patients.46 Another enzyme we examined is Aldo-Keto Reductase family 1 member C1 (AKR1C1), which primarily regulates the synthesis and clearance of sex hormones

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Lohse DL, Denu JM, Santoro N, Dixon JE (1997) Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1